Product Introduction:

Teraparin is a recombinant form of parathyroid hormone consisting of a first (N-terminal) 34 amino acid, which is a biologically active part of the hormone. It is an effective anabolic (ie, bone) agent for the treatment of certain forms of osteoporosis. And sometimes use de-labeling to accelerate fracture healing. Trepipril is identical to a part of human parathyroid hormone (PTH), which is used intermittently to activate osteoblasts than osteoclasts, resulting in an overall increase in bones.

Applications

A fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. This fragment was also found to be an agonist at PTH1 and PTH2 receptors.Recombinant parathyroid hormone, treatment of osteoporosis.

Terapril is the only synthetic metabolic (ie, bone growth) for postmenopausal women with osteoporosis with high risk of fracture or osteoporotic fractures, patients with multiple risk factors for fracture, and failure or failure of patients Tolerate other available osteoporosis treatment. It has been approved by the FDA since 2002. It can effectively grow bones (for example, a year after the spine bone density increased by 8%), and reduce the risk of brittle fracture. Osteoporosis drugs are usually safe, but some side effects of teriparatone include headache, nausea, dizziness and limb pain.

A randomized trial of postmenopausal women with vertebral fractures compared with placebo 20 or 40 micrograms per day compared with teriparatide. About 19 months later, 14% of women taking placebo had new vertebral fractures, while 5% had 20 micrograms of teriparatide and 4% had 40 micrograms. The number of non vertebral fractures in the treatment group was also statistically significant. 20 micrograms of teriparatide increases the mineral density of the spine and hip bone.

Terrapipine is used as a detoxifying agent for accelerating fracture repair and treating nonunion of fractures. It has been reported to have been successfully used to cure fractures without healing. In general, due to HIPAA's regulations, when US athletes receive treatment to improve fracture recovery, and did not publish. But Italian footballer Francesco Totti was given Trinpelp after the tibial / fibula fracture and accidentally restored the 2006 World Cup. It was reported that Mark Mulder used it to recover from the 2005 MLB playoff hip fracture Auckland A, Terrell Owens recovered from the ankle fracture before the 2005 Super Bowl.

Specification:

Product Name: Teriparatide Acetate
Sequence: Cas No.: 52232-67-4
Molecular Formula: C181H291N55O51S2
Molecular Weight: 41177.72
Purity (HPLC): 95.0%min.
Appearance: White powder
Single Impurity (HPLC): 2.0%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ≥80.0%
Water Content (Karl Fischer): ≤10.0%
Acetate Content (HPIC): ≤15.0%
MS (ESI): Consistent
Mass Balance: 95.0~105.0%

Function:

1. APIs; Teriparatide is indicated for use in postmenopausal women with osteoporosis at a high risk for
fracture or with a history of ostoporotic fracture, patients with multiple risk factors for fracture, and for
patients who have failed or are intolerant to other available osteoporosis therapy.

2. Teriparatide is also indicated to increase bone mass in men with primary or hypogonadal osteoporosi
s at high risk of fracture, patients with multiple risk factors for fracture, and for patients who have failed
or are intolerant to other available osteoporosis therapy.
Teriparatide is indicated as well for the treatment of men and women with osteoporosis associated with
sustained systemic glucocorticoid therapy.

3. Teriparatide should not be prescribed for patients who are at increased risks for osteosarcoma.