Pharmaceutical Raw Powder 5-Aminolevulinic Acid Hydrochloride CAS 5451-09-2

Basic Info.

Name:5-Aminolevulinic Acid HCl 

Specification: 99-101% HPLC 

CAS No.: 5451-09-2 

Appearance: Off-white powder

Package:1kg/foil bag or as your inquiry

Package: 1Kg/bag, or at customer's requirements 

Storage: Store in a cool, dry place and keep away from direct strong light. 

Shelf Life: 2 years.

Reference FOB Price:$1/g

MOQ:10g

Specification:ISO9001,USP,BP,GMP

Trade Mark:CQSP

Port:Shenzhen/Shanghai,China

Production Capacity:5000kg/month

Shelf life:2 years

More details pls contact:Whatapp:86 13048470428  

Skype/E-mail : summer at chembj.com

Product Categories:

Active Pharmaceutical Ingredients;Fluorobenzene;Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives;Aliphatics;Carboxylic Acids;Organic acids;Miscellaneous;Porphyrins;Precursers;Plant Growth Trgulators (Others);Biochemistry;Plant Growth Regulators;Dextrins,Sugar & Carbohydrates;Carboxylic Acids;Non-natural amino acids;Amino Acids & Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;LEVULAN;Inhibitors

Function:

5-Aminolevulinic acid hydrochloride Used in cosmetic, PDT and fertilizer

5-Aminolevulinic acid hydrochloride

The metabolism of aminolevulinic acid (ALA) is the first step in the biochemical pathway resulting in heme synthesis. Aminolevulinic acid is not a photosensitizer, but rather a metabolic precursor of protoporphyrin IX (PpIX), which is a photosensitizer. The synthesis of ALA is normally tightly controlled by feedback inhibition of the enzyme, ALA synthetase, presumably by intracellular heme levels. ALA, when provided to the cell, bypasses this control point and results in the accumulation of PpIX, which is converted into heme by ferrochelatase through the addition of iron to the PpIX nucleus.

According to the presumed mechanism of action, photosensitization following application of aminolevulinic acid (ALA) topical solution occurs through the metabolic conversion of ALA to protoporphyrin IX (PpIX), which accumulates in the skin to which aminolevulinic acid has been applied. When exposed to light of appropriate wavelength and energy, the accumulated PpIX produces a photodynamic reaction, a cytotoxic process dependent upon the simultaneous presence of light and oxygen. The absorption of light results in an excited state of the porphyrin molecule, and subsequent spin transfer from PpIX to molecular oxygen generates singlet oxygen, which can further react to form superoxide and hydroxyl radicals. Photosensitization of actinic (solar) keratosis lesions using aminolevulinic acid, plus illumination with the BLU-UTM Blue Light Photodynamic Therapy Illuminator (BLU-U), is the basis for aminolevulinic acid photodynamic therapy (PDT)

5-Aminolevulinic acid hydrochloride Chemical Properties

mp ~150 °C (dec.)

storage temp. 2-8°C

Fp 155-157°C

solubility H2O: 50 mg/mL

Sensitive Hygroscopic

Decomposition 155-157 ºC

Merck 14,446

BRN 3690651

CAS DataBase Reference 5451-09-2(CAS DataBase Reference)

Safety Information

Hazard Codes  

Risk Statements 36/37/38-66-20/21/22-36/38

Safety Statements 26-36/37-37/39-36

WGK Germany 3

RTECS OI1640000

Hazard Note Irritant

Usage

Naturally occurring amino acid; precursor of tetrapyrroles in the biosynthesis of chlorophyll and heme. Antineoplastic (photosensitizer).