1. Quick detail 

Product name: Procaine hydrochloride ;Procaine HCl
Synonyms:aminocaine;anadolor;anesthesol;anestil;atoxicocaine;Benzoicacid,4-amino-,2-(diethylamino)ethylester,monohydrochloride;benzoicacid,p-amino-,2-(diethylamino)ethylester,monohydrochloride;bernocaine
CAS:51-05-8
MF:C13H21ClN2O2
MW:272.77
EINECS:200-077-2
Categories:Pharmaceutical;Anesthetics;Pharmaceutical intermediate
Appearance:white crystalline powder
Assay:99.5%
Usage:Local anesthesic ;Procaine is a local anesthetic of the amino ester group that is primarily used as a topical anesthetic. Procaine is also used to control the pain of intramuscular injection of penicillin as well as in dentistry.

2. Related products:

Benzocaine base: / benzocaine /benzocaine/ procaine / lidocaine / lidocaie hcl / procaine hcl

Produt name:
Benzocaine Powder
Purity: 99.5%
CAS No.: 94-09-7
Appearance: White Crystal Powder
Usage: Local anesthetic.
Standard: USP/BP standard

Lidocaine base
Chemical Name: Lidocaine
Molecular Formula: C14H22N2O
Formula Weight: 234.34
CAS No.: 137-58-6
Pakcage: 25kg/drum
Usage: Local anesthetics

Peoduct name: Lidocaine hydrochloride
Cas: 73-78-9
MF: C14H23ClN2O
MW: 270.7982
Melting point: 350.8° C at 760 mmHg
Usage: Local anesthetics, antiarrhythmic drugs, used for a variety of anesthesia and rapid ventricular arrhythmia

Procaine
Product name: Procaine
CAS No.: 59-46-1
MF: C13H20N2O2
MW: 236.31
Purity: 99%
Appearance: White Crystalline Powder
Place of Origin: China
Standard: USP
Usage: Local anesthetics

3. Procaine HCl Specification

4. Procaine HCl description :

Procaine hydrochloride is a local anesthetic, can temporarily block the conduction of nerve fibers with anesthetic effect, strong role, low toxicity, and no addiction, but the skin, mucous membrane penetration is weak, not suitable for the surface Anesthesia, clinical mainly used for infiltration, spinal and conduction anesthesia.

White needle-like crystalline or crystalline powder at room temperature, odorless, taste slightly bitter and Ma, soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. Hydrochloric acid procaine structure in the ester bond can be hydrolyzed to generate amino acid and diethylamino ethanol, under certain conditions, p-aminobenzoic acid can be further decarboxylation to produce toxic aniline.

The structure of procaine hydrochloride with aromatic primary amino, easy oxidation discoloration pH, temperature, UV, oxygen and metal ions can accelerate the oxidation discoloration. The aqueous solution was stable in pH3.0 ~ 5. So preparation of procaine hydrochloride injection, it generally takes add acid to regulate pH 3.3 to 5.5, and strictly control the sterilization temperature and time. to 100 ℃ steam sterilization 30min circulation is appropriate, and should pay attention to shading, sealed save.

The product structure of aromatic primary amino group in dilute hydrochloric acid can generate diazonium salt with sodium nitrite, coupling reaction occurs when add alkaline β- naphthol, generating azo compounds scarlet.

5. Applications of procaine 

Application of procaine leads to the depression of neuronal activity. The depression causes the nervous system to become hypersensitive producing restlessness and shaking, leading to minor to severe convulsions. Studies on animals have shown the use of procaine LED to the increase of dopamine and serotonin levels in the brain.Other issues may occur because of varying individual tolerance to procaine dosage. Nervousness and dizziness can arise from the excitation of the central nervous system, which may lead to respiratory failure if overdosed. Procaine may also induce weakening of the myocardium leading to cardiac arrest.

Procaine can also cause allergic reactions causing the individuals to have problems with breathing, rashes, and swelling. Allergic reactions to procaine are usually not in response to procaine itself, but to its metabolite PABA. About one in 3000 people have an atypical form of pseudocholinesterase, which does not hydrolyze ester anesthetics such as procaine, resulting in a prolonged period of high levels of the anesthetic in the blood and increased toxicity.

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Packing
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Quality
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Price
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Delivery
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7. Local Anesthetic Drugs lists

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